Role of Punica granatum-derived nanosilver in helminth protection

Pomegranate is a long-known edible fruit with medicinal properties. Helminth infections are among the most common human illnesses worldwide, due to lack of suitable sanitary systems and safe drinking water sources. Although these seldom deadly, they cause development limitations in children, which damage their school performance make them susceptible other illnesses. The present study has been conducted investigate anthelmintic activity silver nanoparticles (AgNPs) synthesized from peel extract (PPE-AgNPs). Also, cytotoxicity PPE-AgNPs was tested liver (Huh7), colon (HCT116) breast (MDA-MB 231) cancer lines. Three doses were used (5, 2.5 1.25 mg/ml) PPE-AgNPs. Eisenia fetida as model worm. Mebendazole reference drug. Phytochemical analysis using FT-IR showed presence 13 compounds. In all tests, dose-dependent effectiveness shown. efficient dose, 5mg/ml time paralysis death 8.118 ± 0.26 9.338 0.14 min, respectively. treated worms, histological examination revealed significant malformation surface architecture worms. We conclude that strong properties low cytotoxicity, stimulating its use biomedical field.